Three nerve cells that surround the brain could be the biological basis of consciousness.
What is the nature of consciousness? This is one of the great mysteries of psychology, neuroscience and the philosophy of mind, and although it may seem curious, research on animals, whose sense of consciousness has to be something different from ours, has helped to clarify it.
In fact, recently a team of researchers from the Allen Institute of Brain Sciences led by Christof Koch has disclosed the discovery of three giant neurons that connect a large part of the brain of mice; Such neurons could be the physiological basis of consciousness, but other experts disagree.
The three giant neurons
Christof Koch and his team made a presentation to members of the neuroscientific community in which they presented the methodology and results of their research on neuronal connectivity in mouse brains.
The most outstanding aspect of his presentation was the identification of three giant neurons that arise from the brain structure known as the “cloister” and connect it with a large part of the brain. The largest of the three reaches around the entire brain, while the other two also encompass a significant portion of the hemispheres.
As revealed by the three-dimensional images obtained from the research, these three cells maintain strong synaptic connections with neurons in many different regions of the brain. This suggests that they may play a relevant role in coordinating the electrochemical impulses of the central nervous system.
However, at the moment the existence of these three neurons has not been confirmed in other animal species, including humans, so great caution must be exercised when trying to generalize the claims of Koch’s team.
What is the cloister?
The cloister is a layer of neurons attached to the lower face of the cerebral neocortex, very close to the insula and the basal ganglia; it is sometimes considered a part of this structure. Its amplitude is irregular, measuring several millimeters in some areas and much less than one millimeter in others.
This region of the brain synapses with many cortical and subcortical structures, including the hippocampus, critical for long-term memory, and the amygdala, involved in emotional learning.
Not only do the neurons of the cloister maintain relevant connections with other parts of the brain, but they are also very closely connected to each other. This has been associated with the uniform processing of stimulation passing through the cloister.
Koch’s team proposal
Based on his recent research and others in which he had previously collaborated, Koch argues that consciousness could be located in the cloister, which has been the main focus of his professional career.
According to the proposal of this team, the three giant neurons that they have found would allow the coordination of nerve impulses in the cloister : they associate the reception and sending of signals from this structure with the appearance of consciousness, taking into account the globality of this transmission and the functions that have been attributed to the cloister.
Another relevant research for this hypothesis is that carried out by the group of Mohamad Koubeissi (2014) with a woman affected by epilepsy. This team found that stimulation of the cloister by electrodes “deactivated” the patient’s consciousness, while interrupting this stimulation caused her to regain it.
The Allen Institute research team triggered the production of fluorescent proteins in individual neurons originating from the cloister of various mice. For this they used a substance that, being present in the organism, caused the activation of certain genes.
By propagating through the target neurons, these proteins gave the entire length of these cells a distinctive color. They then took 10,000 images of sections of the brains and used computer software to create three-dimensional maps of the activated neurons.
Criticisms of this hypothesis
Various experts in the neurosciences have disagreed with Koch’s team’s proposal. In a general way, the localizationism of his hypothesis has been criticized, which attributes to the cloister the main role in human consciousness without being supported by a solid research base.
To study the veracity of these approaches, Chau et al. (2015) conducted a study with 171 war veterans who had suffered head injuries. They found that injuries to the cloister were related to a slower recovery of consciousness after the damage, but not to more serious long-term sequelae.
At the moment the evidence in favor of the hypothesis that the cloister is key to consciousness is inconclusive, especially when it comes to human beings. However, the evidence does suggest that this structure may be relevant for attentional control through the connection of different regions of both cerebral hemispheres.
- Chau, A .; Salazar, AM; Krueger, F .; Cristofori, I. & Grafman, J. (2015). The effect of claustrum lesions on human consciousness and recovery of function. Consciousness and Cognition, 36: 256-64.
- Crick, FC & Koch, C. (2005). What is the function of the claustrum? Philosophical Transactions of the Real Society of London B: Biological Sciences, 360 (1458): 1271-79.
- Koubeissi, MZ; Bartolomei, F .; Beltagy, A. & Picard, F. (2014). Electrical stimulation of a small brain area reversibly disrupts consciousness. Epilepsy & Behavior, 37: 32-35.
- Torgerson, CM; Irimia, A .; Goh, SYM & Van Horn, JD (2015). The DTI connectivity of the human claustrum. Human Brain Mapping, 36: 827-38.